Stress Relief
CalmClarity
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Stress Relief
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CalmClarity

Product Highlights

Reduces the stress and anxiety levels to help you calm down quickly. Assists in increasing mental endurance.
  • A combination of Vitamin B3, magnesium and herbs
  • Maintains and modulates the stress mechanism
  • Supports mood regulation
  • Promotes relaxation
  • This formula is not sold to any retailer as a private label or store brand

    Main Properties

    easy_swallow_capsules, freedom_packet_system, vegan, gluten, non_gmo, no_artificial, made_in_usa, sugar_and_cafeine

    Each packet contains

    Ingredient Details
    Stress relief (blue)
    Stress relief (clear)
    Name & Details Amount per Serving %DV
    Niacin

    (as niacinamide)

    100mg
    625%
    Vitamin B6

    (as pyridoxine HCL)

    100mg
    5880%
    Ashwagandha Powder

    (root)

    300mg
    **
    Eleuthero Powder

    (root) (std. to 0.8% eleutherosides)

    100mg
    **
    Name & Details Amount per Serving %DV
    Magnesium

    (as magnesium glycinate)

    60mg
    15%
    Bacopa Monnieri Extract

    (whole herb) (std. to 20% bacopasides)

    300mg
    **
    Lemon Balm Extract

    (leaf) (std. to 7% rosmarinic acid, 14% hydroxycinnamic acid)

    240mg
    **
    These pills are also part of the following products
    These pills are also part of the following products

    INGREDIENT SCIENTIFIC REVIEW

    Brahmi, Bacopa Monnieri
    Wrriten by Simon Ido | MCS. Forwarded by Prof. Shoseyov Oded

    Bacopa monnieri, Brahmi

    Written by: Simon Ido | MSc
    Forwarded by; Prof. Shoseyov Oded. Estimated reading time 5 min, 42 seconds
    Last update, AUG, 2021

    HIGHLIGHTS 

    Bacopa monnieri a creeping plant considered in the Ayurvedic system as a herb to boost memory [3]

     

    Brahmi contains Bacosides which are a family of saponins with unique neuroprotective and adapto- genic effects on the CNS[5,7] 

     

    Brahmi has double-blind, randomized, placebo- controlled studies in humans demonstrating its nootropic and adaptogenic effects[1,2,3,4,5] 

    BACKGROUND

    Bacopa monnieri, otherwise known as Brahmi, is a creep- ing plant inhabiting marshy areas, and is considered in the Indian Ayurvedic system of medicine as a "memory booster herb"[3]. Constituent analysis of Brahmi shows that most of its activity is derived from the presence of al- kaloids and triterpenoids[3] - more specifically the family of saponins known as Bacosides A and B, which encompass at least 12 purified compounds so far[7]. There is some evidence to suggest that extracts of Brahmi may be beneficial in improving cognitive function in the attention domain, especially speed of attention[4], learning, and memory with chronic administration[6]. Research into the mechanism of action for the effects of Brahmi has shown cholinergic, antioxidant, and adaptogenic effects in the central nervous system[5].

    Brahmi’s traditional use as a memory booster is bolstered by modern studies, many of which are random

    ized double-blind placebo-controlled trials which sub- stantiate the memory boosting and nootropic effects of Brahmi[1, 4, 5], especially in older populations which are particularly sensitive to neurological conditions ranging from mild memory loss to Alzheimer’s Disease.

    MODE OF ACTION

    Although the mechanisms for Brahmi’s neuroprotective and nootropic effects have not yet been fully elucidated. With over 12 unique steroidal saponins[7] and at least 8 other pharmacological constituents including alkaloids and alcohols[3], the exact mode of action is complex and varies based on dosage and chronic administration.

    The first mode of action by which Brahmi works is

    through its antioxidant activity, which has been shown to upregulate expression of various antioxidant molecules such as SOD and glutathione, as well as quenching hy- drogen peroxide-mediated oxidative stress both in-vitro and in-vivo[3]. Another study which examined rat brains treated with Brahmi extracts showed a significant re- gression of Heat-shock protein 70 (Hsp70) in rats given stress after treatment, which may hint at Brahmi’s lo- calized effectiveness in the hippocampus[2] and also has implications for the reduction of protein aggregation in the brain duet alpha-synuclein[1]. It was also seen that treatment with the Brahmi extracts modulated the ac- tivity of the P450 enzymes[2], which are known to be involved in ROS scavenging, however further research needs to be performed to elucidate the role of these en- zymes in relation to Brahmi’s mode of action. It was also seen in rats that administration of intravenous backside A inhibited lipid peroxidation, improved the activities of ATPases, and maintained ionic equilibrium (including zinc and selenium) in brans of cigarette smoke-exposed rats[1]. Brahmi was also found in rat models to increase the Nrf2 and Nf-kappa β transcription factors[3], which are two major transcription factors involved in the an- tioxidant machinery of cells. In addition, the Brahmi extract in itself has shown radical scavenging potential and reduction of nitrogen radicals in vitro[1, 3].

    Brahmi also has neuroprotective effects, especially against inflammation in diseases such as Alzheimer’s. For instance, even lower doses of Brahmi extract treat- ment (in vitro) were found to reduce the interleukin and TNF-α levels in microglial cells which are part of the known immunoligcal pathways involved in Alzheimer’s Disease[3]. In rat models of Alzheimer’s, Brahmi was found to reverse memory impairment, reduce lipid per- oxidation and protein carbonyl levels,  and also restore the activity of some anti-oxidant enzymes[1].  In aged

    rat brains, Brahmi also restored acetylcholine levels and monoamine levels to concentrations seen in young rats, which elucidates that one of the mechanisms of Brahmi is through choline acetyltransferase activation rather than acetylcholine esterase inhibition[1]. This study not only showed that potentiation of monoamine and 5-HTP were through a non-obvious cellular mechanism, but also that there was a mild antidepressant effect associated with this mechanism in rats[1].  It was also found that one of the bioactive components of Brahmi, Betulinic acid, reduced pro-inflammatory responses in cell lines by re- ducing the COX-2 expression and prostaglandin E2 pro- duction, as well as attenuating the Akt and ERK sig- naling cascades[3]. Through similar neuroprotective and anti-inflammatory mechanisms, there is also similar pre- clinical evidence suggesting that Brahmi could be useful in treating Parkinson’s Disease[1, 3]. As with Ashwa- gandha, Brahmi has also been found to inhibit Amyloid- β-mediated toxicity associated with Alzheimer’s[3]. One of the key differences between Ashwagandha and Brahmi is that one of the bioactive components of Brahmi, Baco- side A, directly dissolves the matured Amyloid-β aggre- gates in cells, and has limited evidence suggesting that it can cross the blood-brain barrier in mouse models[3].

    PHARMACOLOGICAL EFFECTS

    Brahmi has multiple effects which are mainly anti-inflammatory, antioxidant, adaptogenic, and nootropic [5], which lend the Ayurvedic herb to a few different uses.

    Brahmi has been shown in double-blind, placebo- controlled, randomized human trials to improve memory with results comparable to modafinil [1, 6]. Researchers also found that although Brahmi did not improve the rate of learning, that the rate of forgetting was significantly attenuated in word-pair trails after 3 months of chronic use[1, 5]. Increased verbal recall was also noted, which supports the alleged use of Brahmi in Vedic antiquity by scholars memorizing lengthy rhythms[1]. This also means that Brahmi has potential for positive pharmacological effects in those suffering from neurodegenerative disorders, especially as an agent for mild improvements in cognitive behavior in both animal and human studies[3].

    As an adaptogenic compound, there is  evidence present in rat models that Brahmi is able to reduce the amount of stress-related compounds produced and has good potential to allow for better brain function under adverse stress events[2]. Additionally, Brahmi has been shown to protect against neuroinflammation and regu- late cell metabolism which could be useful pharmacological effects agains neurodegenerative diseases[3].

    POTENTIL USE

    As described above, Brahmi has complex mechanisms of action which ultimately lead to its popular use in adaptogenic and nootropic applications - hence its popularity as a "memory booster" herb[3].

    Most of Brahmi’s activity is derived from the presence of alkaloids, triterpenoids, and saponins known as Bacosides[3], of which over 12 different kinds exist[7]. Thus its potential use can vary, however, the most vet- ted and researched usage, both in animal trials and randomized double-blind placebo-controlled trials, is as an anti-inflammatory and nootropic[1, 4, 5]. This makes it a potential medicine to be used in conjunction with tra- ditional medicines for neurodegenerative diseases such as Alzheimer’s or amnesia[1, 5].

    More research still needs to be done in terms of the consistency of pharmacological constituents, effects of different Bacosides, and mitigation of negative intestinal side effects before Brahmi can become widely used in mainstream medicine[1, 3, 5].

    REFERENCES

    [1] C. Aguiar and T. Borowski. Neuropharmacological review of the nootropic herb bacopa monnieri. RE- JUVENATION RESEARCH, 16(4):313–325, 2013.

    [2] D.K. Chowdhuri, D. Parmar, P. Kakkar, R. Shukla, P. K. Seth, and R. C. Srimal. Antistress effects of bacosides of bacopa monnieri: modulation of hsp70 expression, superoxide dismutase and cytochrome p450 activity in rat brain. Phytotherapy Research, 16(7):639–645, 2002.

    [3] T. Dubey and S. Chinnathambi. Brahmi (bacopa monnieri): An ayurvedic herb against the alzheimer’s disease. Archives of Biochemistry and Biophysics, 676:108153, 2019.

    [4] C. Kongkeaw, P. Dilokthornsakul, P. Tha- narangsarit, N. Limpeanchob, and N. Scholfield. Meta-analysis of randomized controlled trials on cognitive effects of bacopa monnieri extract. Journal of Ethnopharmacology, 151(1):528–535, 2014.

    [5] A. Morgan and J. Stevens. Does bacopa monnieri improve memory performance in older persons? re- sults of a randomized, placebo-controlled, double- blind trial. The Journal of Alternative and Com- plementary Medicine, 16(7):753–759, 2010. PMID: 20590480.

    [6] C. Neale, D. Camfield, J. Reay, C. Stough, and A. Scholey. Cognitive effects of two nutraceuticals ginseng

    Read More
    Neuroanatomy of stress
    Wrriten by Maya Gosztyla | Neuroscience and Molecular Genetics. Double B.S. degree

    Neuroanatomy of stress

    Estimated reading time 5 Min, 42 Sec
    Last update, Aug, 2021

    It’s been a stressful year. With many countries grappling with thorny social and political issues, compounded upon by a global pandemic, it’s no surprise that so many of us are feeling strained. The American Psychological Association has declared stress to be a national mental health crisis, reporting that many Americans experienced unwanted weight changes, sleep disruptions, or other signs of worsening stress since the start of the pandemic.

     

    Beyond its effects on mental health, stress can also have a strong impact on our biology. In this article, we’ll talk about what stress really means in a biological sense, with a particular focus on its effects on the brain.

     

    WHAT IS STRESS EXACTLY? 

    Stress can have multiple meanings depending on who you ask. To a psychologist, stress is a subjective mental experience. To a biologist, it is something more concrete. Stress is something that can alter nearly every aspect of your biology, including how your cells repair damaged DNA, degrade misfolded proteins, or keep cancer at bay. It even impacts the process of aging.

    Stress is one of our most primitive emotions. It is tied to our flight-or-fight response, an instinct that evolved to protect our ancestors from predators and other dangers. When you realize you forgot an important deadline at work, the same basic circuits are being activated in your body as when you ancestor encountered a lion in the wild. A racing heart, sweaty palms, and other classic signs of stress would have prepared your ancestor to fight the lion or flee to safety. In the modern day, these biological reactions are less helpful for dealing with everyday stressors.

    The opposite of stress is homeostasis, also called rest-and-digest. When no danger is present, your heartrate slows, your muscles relax, and your gastrointestinal tract resumes digesting food (digestion is an energy-intensive process, so it’s paused during times of perceived danger). Periods of homeostasis are crucial for our minds and bodies to remain healthy.

    THE WORLD OF STRESS HORMONES

    The nervous system is the key regulator of stress, so let’s talk neuroanatomy. One important term is the autonomic nervous system, which arises from neurons in your spinal cord. This system controls involuntary bodily processes, such as the activities of your internal organs.

    The autonomic nervous system can be further divided into two categories: the sympathetic nervous system, which is active during periods of stress, and the parasympathetic nervous system, which is active during homeostasis. When you encounter a stressful trigger, the sympathetic nervous system activates almost instantaneously, flooding your body with stress hormones called epinephrine and norepinephrine. These hormones act quickly to prepare you for potential danger by raising your heartrate and sweat levels.

    A few seconds later, these hormones activate a secondary stress circuit called the hypothalamic-pituitary-adrenal axis, or HPA axis for short. As the name implies, the HPA involves three different regions. The hypothalamus is a brain region located just above the brainstem, which senses stress hormones in the bloodstream and sends a signal to the pituitary gland, a pea-sized brain structure located behind the bridge of your nose. The pituitary is sometimes called the “master gland,” as it can signal to many of the other glands in your body as well as release its own hormones.

    When it has been activated, the pituitary gland relays the signal to the adrenal glands located top of the kidneys, which in turn release another hormone called cortisol into the bloodstream. Unlike epinephrine and norepinephrine, which are meant for immediate responses, cortisol helps you respond to longer-lasting stressors. For example, it increases your blood pressure and blood sugar levels, both of which prepare you for physical exertion in the face of danger. It also inhibits less crucial processes including digestion and libido.

    YOUR BRAIN ON STRESS

    The hypothalamus and pituitary gland aren’t the only brain regions involved in stress. Once cortisol is released into the bloodstream, it can have widespread impacts on the rest of the brain. The hippocampus, a brain region best known for its role in memory, is particularly sensitive to cortisol. Studies have found that stress causes fewer neurons to be born in the hippocampus, and it can also alter the structure of neuronal connections. As a result, chronic stress can cause the hippocampus to become smaller over time, with some studies suggesting that memory formation can become impaired as well.

    Another important brain region is the prefrontal cortex, which is important for advanced brain functions like long-term planning, impulse control, and social behavior. Chronic stress can alter neuronal connections in the prefrontal cortex and lead to gradual atrophy of this region. In contrast, another brain region called the amygdala appears to become larger with repeated stress. The amygdala is important for processing negative emotions, particularly fear and anger. A hyperactivate amygdala may contribute to anxiety or aggressive behavior.

    IS STRESS A BAD THING?

    If you follow psychology research, you may be familiar with terms like eustress and distress, i.e, “good stress” and “bad stress.” The criteria for these two types of stress are somewhat vague, but eustress is generally used to describe stress that helps you to achieve a goal, like the anxiety from an upcoming deadline that motivates you to get over your laziness and finish an assignment. In contrast, distress is an impediment to your goals, such as when your responsibilities feel so insurmountable that you become too overwhelmed to focus on anything.

    The eustress vs. distress paradigm has been criticized by some scientists, who believe that the distinction is not so clear-cut. At the cellular level, there does not appear to be much difference between “good” or “bad” stress, as the same signaling pathways are activated regardless of whether the stress is helpful or not. However, this is an area of neuroscience research that’s still relatively new, and it’s likely that new findings will shed more light on the topic in future years. In the meantime, many psychologists still find the distinction useful for helping individual recognize when they are approaching unhealthy levels of stress. If you feel that your stress is starting to interfere with your activities of daily life, there are many science-backed techniques for dealing with stress. These include getting regular exercise, avoiding tobacco products, and practicing relaxation techniques.

     

    NEUROANATOMY SUMMERY

    ∙ Hypothalamus: The hypothalamus is one of the brain’s main signaling hubs. In the context of stress, it senses stress hormones in the bloodstreams and sends signals via the HPA axis.
    ∙ Pituitary gland: The pituitary gland is the “master gland,” controlling hormone release from many other glands throughout the body. When signaled by the hypothalamus, it relays to the adrenal glands to release the stress hormone cortisol.
    ∙ Hippocampus: The hippocampus is crucial for memory formation. Stress can cause it to atrophy over time.
    ∙ Prefrontal cortex: The prefrontal cortex controls advanced behaviors like long-term planning, impulse control, and social behavior. Stress can cause it to atrophy over time.
    ∙ Amygdala: The amygdala controls emotions like fear and anger. Stress can cause an enlarged and hyperactive amygdala.

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    USER TESTIMONIALS

    FAQ

    How long does it take before you start feeling results? Most customers report relief in stress within 30 minutes from intake. For individuals experiencing ongoing stress for a while now, it’s recommended to take Stress Relief for 45 to 60 days with a combination of physical activity and or Meditation practice. This will help you reduce the stress level set point. After 60 days, take as needed.
    Do I have to take both capsules at the same time? Yes. recommended use is to take both capsule at the same time. if your known to have a sensitive stomach you can take one capsule, wait for 30 minutes and take the second capsule.
    What is your 30-day money-back guarantee? We formulated the products with your brain on our mind . If for some reason the product didn't work for you, let us know and we'll process your refund.

    a word from our team

    Nir Avraham, MSc. Biochemistry

    Master Formulator

    “The most exiting part in creating our proprietary formulas was witnessing first hand how today’s science proves anciant knowlage”

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