Brain Focus
cognitionenergy
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Brain Focus
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cognitionenergy

Product Highlights

A full-spectrum brain-enhancing proprietary formula, Brain Focus increases your entire brain’s functioning with Rhodolia rosea, Ginseng, Gingko bilboa, and more. Allowing you to focus easily and with greater clarity.
  • Improves mental focus
  • Helps strengthen clarity
  • Supports short term memory
  • Improves cognition
  • This formula is not sold to any retailer as a private label or store brand

    Main Properties

    easy_swallow_capsules, freedom_packet_system, vegan, gluten, non_gmo, no_artificial, made_in_usa, sugar_and_cafeine

    Each packet contains

    Ingredient Details
    Brain focus (blue)
    Brain focus (clear)
    Name & Details Amount per Serving %DV
    Centella Extract

    (whole herb)

    160mg
    **
    Ginkgo Biloba Extract

    (leaf)

    120mg
    **
    Guarana Extract

    (seed)

    100mg
    **
    Paeonia lactiora Extract

    60mg
    **
    Alpha GPC

    40mg
    **
    L-Glutamine

    40mg
    **
    N-Acetyl L-Tyrosine

    40mg
    **
    N-Acetyl N-Carnitine

    40mg
    **
    Huperzine A

    (leaf)

    100mcg
    **
    Name & Details Amount per Serving %DV
    Panax ginseng Extract

    (herb)

    180mg
    **
    Rhodiola Extract

    (root)

    160mg
    **
    Rosemary Extract

    (aerial part)

    120mg
    **
    Rhodiola Dry Root Powder

    60mg
    **
    DMAE

    40mg
    **
    Phosphatidylserine

    (20%)

    40mg
    **
    These pills are also part of the following products
    These pills are also part of the following products

    INGREDIENT SCIENTIFIC REVIEW

    Ginseng Root
    Wrriten by Simon Ido | MCS. Forwarded by Prof. Shoseyov Oded

    Ginseng Root

    Written by: Simon Ido | MSc
    Forwarded by; Prof. Shoseyov Oded. Estimated reading time 5 min, 42 seconds
    Last update, Jul, 2021

    HIGHLIGHTS 

    Ginseng, a traditional folk medicine, is a medici- nal root containing steroid and saponin molecules known as ginsenosides[6].

     

    Considered largely safe[4], ginseng has a wide range of effects on multiple body systems[1, 2], thought to be through the regulation of cellular responses in different tissues[1].

     

    Ginseng has been recommended by some researchers as a complementary and alternative medicine[5] for a wide variety of conditions including Alzheimer’s disease and Parkinson’s disease[2, 3].

    BACKGROUND

    Ginseng is the medicinal root of the Panax ginseng, P. quinquefolius, or P. japonicus - Asian, American, and Japanese, respectively - and has been widely used in folk medicine for the past 2000 years for the treatment of various conditions[6]. The major bioactive components of ginseng are the group of saponins known as ginseno- sides, of which over 50 have been found[6]. More modern research has also shown that polysaccharides also con- tribute a key role in the bioactivity of ginseng[7]. Addi- tionally, the type of ginseng and the way that it is ex- tracted has also been found to play a role in the efficacy of treatment[2].

    Ginseng is reported to have multiple effects, includ- ing adaptogenic properties, neuroprotection, relaxing of smooth heart muscles, anti-inflammatory, and immunos- timulant attributes[5].

    Ginseng’s efficacy regarding psychologic functioning is conflicted, while its efficacy on the immune system is considered effective[5].

    Ginseng is considered to be largely safe, as reported in dogs, rats, and humans[4], however, it is possible to experience unwanted side effects such as hypertension from excessive ginseng intake[4]. Another, more recent safety and efficacy review, concluded that while some studies indicated adverse effects such as constipation, hot flushes, or insomnia - that placebo-controlled clinical trials showed no statistical significance between ginseng and placebo groups regarding both the frequency and type of adverse symptoms[3]. More safety and efficacy studies need to be performed in order to draw definitive conclusions about ginseng’s safety and potential adverse effects.

     

    MODE OF ACTION

    The exact mode of action of ginseng’s bioactive com- pounds has not yet been fully elucidated across the variety of ginseng types and extracts.  However, the mode of action of ginsenosides has been researched fairly extensively and some conclusions can be presented for cell lines, animal models, and limited human clinical trials. Ginsenosides are ampiphilic in nature, and have the ability to insert into the plasma membrane - eliciting a cellular response[1].

     

    Ginseng and ginsenosides affect the central nervous system (CNS) through a variety of mechanisms, namely by affecting the neurotransmission of acetyl choline and gamma-aminobutyric acid (GABA) by enzymatic ex- pression, altering brain plasticity and neurogenesis, and affecting a plethora of voltage-gated ion channels[2]. Ginseng exhibits both stimulatory and inhibitory effects on the CNS, with different ginsenosides playing different roles for different CNS cell types[1].

     

    In cell lines, anti-tumor  activity  has  been  found  to be related to the effect of polysaccharides present in ginseng extracts  in  regulating  the  M2/G  cycle  phase of cell division[7]. In other cell lines, the polysaccha- rides were found to also increase the levels of TNF-α and interleukin-1[7]. Ginseng and ginsenosides have also shown to be neuroprotective agents in human cell lines through phosphorylation, induction of apoptosis, and prevention 

    of free radical species[2].

     

    Ginseng’s immunomodulatory effect has found to be related to regulation of cyclooxygenase (COX)-1 expression, in addition to stimulating natural killer cells, T- cells, and macrophages[7].

    The mode of action in which ginseng works as an anti- inflammatory is not yet entirely clear. 

    The regulation of the inflammatory response by ginseng and ginsenosides is regulated by cell type and the specific ginsenoside 

    composition and is involved in a plethora of cellular signaling pathways[2]. One of the most widely documented modes of action for the antioxidant effects in vitro has the been the inhibition of hydroxyl radicals across a wide variety of as- says and cell lines[4]. In vivo, there have been many re- sults showing tissue antioxidant activity, mainly through modulation of tissue enzymatic activity and 

    nitric-oxide receptor genes[4].

     

    PHARMACOLOGICAL EFFECTS

    Ginseng exhibits a diverse variety of pharmacological effects due to the large variety  of  ginsenosides  and other plant bioactive constituents[1]. Ginsenosides are steroidal and saponin molecules, exhibiting similar form- function characteristics. Ginseng has been recommended by some researchers as a complementary and alternative medicine[5] for a wide variety of conditions.

    Animal models have shown that ginseng extracts were effective in combating depression-like and stress-related behaviors[2]. In mice, there is conflicting evidence for the anxiolytic effect of ginseng, with some studies showing an effect comparable to diazepam and other studies showing no effect at all[2].

    In early human clinical trials of ginseng extract for Alzheimer’s disease, it was shown that a 12-week treat- ment of encapsulated P. ginseng powder increased cog- nitive performance, and that taking away the extract resulted in a cognitive decline back to baseline[2].

    Other therapeutic roles of ginseng include protection against diabetic retinopathy, neural stem cell prolifera- tion, protection from oxidative stress and apoptosis, at- tenuation of pathogen virulence factor production, treat- ment of erectile dysfunction, and alleviation of fatigue in multiple sclerosis[5]. Additionally, some polysaccharides in gingseng exhibit activities which lower blood sugar[7],

    and can be useful as a part of certain diabetic treat- ments. In addition, ginseng has the ability to modulate insulin secretion by encouraging glucose-related insulin release in pancreatic β-cells[6].

    POTENTIL USE

    As described above, ginseng has a complex effect on multiple body systems, including the CNS[1, 2], im- mune system[7], and inflammatory and homeostatic systems[2, 4].

    Ginseng is recommended by many researchers as a complementary alternative medicine to many treatments and for a wide range of conditions including neurodegenerative and inflammatory diseases[1, 2, 5, 7] - however it is important to note that these uses are based on animal models and cell cultures[6]. Thus, more placebo double-blind human clinical studies are needed to truly determine the best use for ginseng and its components.

    REFERENCES

    [1]     A. Attele, J. Wu, and C. Yuan. Ginseng pharma- cology: Multiple constituents and multiple actions. Biochemical Pharmacology, 58(11):1685–1693, 1999.

     

    [2] H. Kim, P. Kim, and C. Shin. A comprehensive re- view of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous sys- tem. Journal of Ginseng Research, 37(1):8–29, 2013.

    [3] Y. Kim, J. Woo, C. Han, and I. Chang. Safety anal- ysis of panax ginseng in randomized clinical trials: A systematic review. Medicines, 2(2):106–126, 2015.

    [4] D. Kitts and C. Hu. Efficacy and safety of ginseng.

    Public Health Nutrition, 3(4a):473–485, 2000.

    [5] M. Shahrajabian, W. Sun, and Q. Cheng. A review of ginseng species in different regions as a multipurpose herb in traditional chinese medicine, modern herbol- ogy and pharmacological science. Journal of Medic- inal Plants Research, 13(10):213–226, 2019.

    [6] J. Wee, K. Mee, and A. Chung. Biological ac- tivities of ginseng and its application to human health. In I. Benzie and S. Wachtel-Galor, editors, Herbal Medicine: Biomolecular and Clinical Aspects, chapter 8. CRC Press/Taylor Francis, Boca Ra- ton (FL), 2nd edition edition, 2011. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92776/.

    [7] B. Zhao, C. Lv, and J. Lu. Natural occurring polysac- charides from panax ginseng c. a. meyer: A review of isolation, structures, and bioactivities. International

    Read More
    Bottom-Up and Top-Down attention
    Wrriten by Maya Gosztyla | Neuroscience and Molecular Genetics. Double B.S. degree

    WRITTEN BY MAYA GOSZTYLA. Estimated reading time 4 min, 21 seconds
    Last update, Dec, 2021

    Bottom-Up and Top-Down Attention

    We are currently living in what has been dubbed the new attention economy. Psychologists and economists argue that consumers’ attention spans are a finite and valuable resource for which companies compete. The evidence for this is all around us: clickbait news headlines, overly-dramatic YouTube thumbnails, and apps pinging your phone with constant notifications are all vying for your attention. With the internet and its limitless information always at our fingertips, is it any wonder that many of us are having trouble focusing?

     

    In this article, we’ll take a deep dive into the neuroscience of attention and discuss several external factors that can impact our ability to focus.

    BOTTOM-UP AND TOP-DOWN ATTENTION

    As living beings, we are constantly bombarded with external stimuli. If your brain were to pay attention to every tiny sound in your surroundings or the dust motes floating through your peripheral vision, you’d never be able to focus on anything important. Focus can thus be defined as our ability to filter out unimportant information while leaving behind that which merits our attention.

    Neuroscientists divide attention into two broad categories. Bottom-up attention occurs unconsciously, like how you automatically notice when your phone buzzes in your pocket. Top-down attention is under conscious control. It’s what you’re choosing to focus on, even if the subject isn’t inherently interesting, like an important school or work project.

    These two types of attention utilize completely different circuits in your brain. The specific pathways depend on which sense you use to detect the stimulus. Let’s focus on visual stimuli here, since this form of attention is the most thoroughly studied.

    The bottom-up attention pathway for visual stimuli begins in the primary visual cortex, located at the back of the brain. From there the signal splits into two pathways. The upper pathway decodes the object- and feature-level properties of the visual stimulus (what is it and what does it look like?), while the lower pathway decodes the spatial- and movement-level properties (where is it now and where is it going?). The two pathways reunite at the prefrontal cortex in the front of the brain, which ultimately controls our attention and decision-making processes.

    While the signals travel from the back to the front of the brain, unconscious neural processes attempt to determine how much we ought to focus on this particular stimulus. Your brain takes into account the background signal, i.e., how much does this stimulus stand out in the current context? A brightly colored outfit would draw your attention more at a somber funeral than at a music festival. 

     

    Top-down attention is very different. Current evidence suggests that the signals for top-down attention do not original from external stimuli but from within our own brains, particularly the prefrontal cortex and the posterior parietal cortex. These two brain regions are where our more advanced neural processes, such as logic, planning, and emotional control, can have a say in where we direct our focus. Top-down attention is still poorly understood compared to bottom-up attention, due to its high level of complexity within the brain.

     

    IMPACT OF SLEEP AND STRESS ON FOCUS

    Focus can be modulated by a variety of external factors. As we covered in a previous article, sleep is crucial for the health of our brains and bodies. Recent research has found that sleep also plays a huge role in attention. Study participants perform worse on attentional tasks the longer they go without sleep, and chronic sleep deprivation can have even worse effects. Studies report that the prefrontal cortex and posterior parietal cortex become less active with sleep deprivation, making it increasingly difficult to maintain top-down attention. Other studies have found that activity in the visual cortex is also reduced, suggesting impairment of bottom-up attention as well.

    Sleep deprivation is also correlated with increased activity of the default mode network. This network becomes active when you are awake but not actively focused on anything, i.e., daydreaming. When you are sleep deprived, your brain’s ability to switch from the default mode network to attentional circuits becomes impaired, making it more difficult you to keep your mind from wandering.

    Stress is another important factor that can impact our ability to focus. Short-term or acute stress generally seems to improve focus. One possible explanation is that a temporary increase in stress hormone levels could signal to your brain that this task particular is important and worthy of our limited attention. (It’s important to note that this may not be true for children, who show worsened focus when in acute stress.) In contrast, long-term or chronic stress has the opposite effect. People experiencing chronic stress have slower response times and worse accuracy on attentional tasks.

    CONCLUTION

    As we’ve discussed, focus is a complex process requiring many different parts of the brain. Despite its complexity, there are many strategies we can employ to improve focus in our everyday lives. Since bottom-up focus is under unconscious control, try to limit distractions that could involuntarily break your focus, such as email notifications or phone calls. To improve top-down focus, prioritize getting enough sleep and maintaining a healthy brain. You can employ acute stress to help you focus in the short-term, but beware of chronic stress, which can have broader brain consequences and may be more difficult to reverse.

    Read More

    USER TESTIMONIALS

    FAQ

    How quickly can I expect to feel results? Most customers report increased concertation within 30 minutes. for best results take capsules with a clear understanding of the mission you're looking to focus on.
    Do I have to take both capsules at the same time? Yes. recommended use is to take both capsule at the same time. if your known to have a sensitive stomach you can take one capsule, wait for 30 minutes and take the second capsule.
    What is your 30-day money-back guarantee? We formulated the products with your brain on our mind . If for some reason the product didn't work for you, let us know and we'll process your refund.

    a word from our team

    Nir Avraham, MSc. Biochemistry

    Master Formulator

    “The most exiting part in creating our proprietary formulas was witnessing first hand how today’s science proves anciant knowlage”

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